JURNAL INTERNASIONAL

Journal of Theoritical and Apllied Information Technology

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Multiple sequence alignment (MSA) is a cornerstone process in computational biology and bioinformastics and it is necessary for sequence analysis. Through decades of extensive research to solve the MSA problem, numerous methods have been proposed and developed. Dynamic progamming-based methods suffer from the high computational cost in building MSA> Therefore researchs tend to solve MSA problem using heuristic methods as they attempt to reach optimal results in a reasonable time. Progessive alignment method is the most used method for constructing MSA. In this paper we present an extensive analysis for the leading methods and top performing methods in MSA. The leading metods of MSA are discussed individually to higlight the differences in methods and techniques they use beside the progessive alignment. Also,we present a critical analysis for MSA leading methods based on experimental results where BaliBASE database is used as a benchmark. Results show that MSAProbs ALgorithm has the superior accuracy performance over all leading methods while MUSCLE and Clustal W are the fastest. Althought numerous algorithms have been proposed for MSA. producing an efficient MSA with high accuracy reamins a huge challenge.

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Ketersediaan

B.03220031

004.0285 JATIT J JurnalInternasional

Perpus STMIK (Jurnal Internasional)

Tersedia

Informasi Detail

Judul Seri

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No. Panggil

004.0285 JATIT J JurnalInternasional

Penerbit

USA : JATIT., 2015

Deskripsi Fisik

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Bahasa

English

ISBN/ISSN

1992 8645

Klasifikasi

004.0285

Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

Volume 75 Nomor 1 Tahun 2015

Subjek

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Info Detail Spesifik

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Pernyataan Tanggungjawab

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Versi lain/terkait

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